In our current research, sucrose palmitate (SP) was applied as a possible permeation\nenhancer for buccal use. This route of administration is a novelty as there is no literature on the use\nof SP in buccal mucoadhesive films. Films containing SP were prepared at different temperatures,\nwith different concentrations of SP and different lengths of hydroxypropyl methylcellulose (HPMC)\nchains. The mechanical, structural, and in vitro mucoadhesive properties of films containing SP were\ninvestigated. Tensile strength and mucoadhesive force were measured with a device and software\ndeveloped in our Institute. Positron annihilation lifetime spectroscopy (PALS) and X-ray powder\ndiffractometry (XRPD) were applied for the structure analysis of the films. Mucoadhesive work was\ncalculated in two ways: from the measured contact angle and compared with direct mucoadhesive\nwork, which measured mucoadhesive force, which is direct mucoadhesion work. These results\ncorrelate linearly with a correlation coefficient of 0.98. It is also novel because it is a new method for\nthe determination of mucoadhesive work.
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